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1

Therapeutic Vaccination against Metastatic Carcinoma by Expression-Modulated and Immunomodified Autologous Tumor Cells: A First Clinical Phase I/II Trial

Wittig, Burghardt, Märten, Angela, Dorbic, Tomislav, Weineck, Silvia, Min, Heshon, Niemitz, Sigrun, Trojaneck, Beate, Flieger, Dimitri, Kruopis, Susanne, Albers, Andreas, Löffel, Jürgen, Neubauer, And

Journal:

Human Gene Therapy

Year:

2001

Language:

english

File:

PDF, 340 KB

english, 2001

2

Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703

Schmidt, Manuel, Hagner, Nicole, Marco, Alberto, König-Merediz, Sven A., Schroff, Matthias, Wittig, Burghardt

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2015

Language:

english

File:

PDF, 1.04 MB

english, 2015

3

TLR2-activated human langerhans cells promote Th17 polarization via IL-1β, TGF-β and IL-23

Ehsan Aliahmadi, Robert Gramlich, Andreas Grützkau, Manuel Hitzler, Melanie Krüger, Ria Baumgrass, Maximilian Schreiner, Burghardt Wittig, Reinhard Wanner, Matthias Peiser

Journal:

European Journal of Immunology

Year:

2009

Language:

english

File:

PDF, 333 KB

english, 2009

4

Immunotherapy of acute lymphoblastic leukemia by vaccination with autologous leukemic cells transfected with a cDNA expression plasmid coding for an allogeneic HLA class I antigen combined with interleukin-2 treatment

G. Henze, A. Borgmann, Arend von Stackelberg, Eckehard Baumgarten, Barbara Uchanska-Ziegler, Andreas Ziegler, Burghardt Wittig

Journal:

Journal of Molecular Medicine

Year:

1998

Language:

english

File:

PDF, 183 KB

english, 1998

5

Priming of immune responses to hepatitis B surface antigen with minimal DNA expression constructs modified with a nuclear localization signal peptide

Reinhold Schirmbeck, Sven A. König-Merediz, Petra Riedl, Marcin Kwissa, Florian Sack, Matthias Schroff, Claas Junghans, Jörg Reimann, Burghardt Wittig

Journal:

Journal of Molecular Medicine

Year:

2001

Language:

english

File:

PDF, 168 KB

english, 2001

6

Surface-enhanced Raman scattering: a new optical probe in molecular biophysics and biomedicine

Janina Kneipp, Burghardt Wittig, Henrik Bohr, Katrin Kneipp

Journal:

Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta)

Year:

2010

Language:

english

File:

PDF, 372 KB

english, 2010

7

The promoter of the HaCaT keratinocyte differentiation-related gene keratin 4 contains a functional AP-2 binding site

R. Wanner, Juan Zhang, Tomislav Dorbic, Dietmar Mischke, Beate M. Henz, Burghardt Wittig, Thomas Rosenbach

Journal:

Archives of Dermatological Research

Year:

1997

Language:

english

File:

PDF, 60 KB

english, 1997

8

The loss of desmosomes after retinoic acid treatment results in an apparent inhibition of HaCaT keratinocyte differentiation

R. Wanner, Bianca Wolff, Fabian Glowacki, Gerhard Kolde, Burghardt Wittig

Journal:

Archives of Dermatological Research

Year:

1999

Language:

english

File:

PDF, 349 KB

english, 1999

9

Ballistic CTLA4 and IL-4 gene transfer into the lower lid prolongs orthotopic corneal graft survival in mice

Er-Ping Zhang, Jürgen Franke, Matthias Schroff, Claas Junghans, Burghardt Wittig, Friedrich Hoffmann

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

2003

Language:

english

File:

PDF, 342 KB

english, 2003

10

Novel optical nanosensors for probing and imaging live cells

Janina Kneipp, Harald Kneipp, Burghardt Wittig, Katrin Kneipp

Journal:

Nanomedicine: Nanotechnology, Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 1.66 MB

english, 2010

11

Keratinocytes Rapidly Readjust Ceramide-Sphingomyelin Homeostasis and Contain a Phosphatidylcholine-Sphingomyelin Transacylase

Wanner, Reinhard, Peiser, Matthias, Wittig, Burghardt

Journal:

The Journal of Investigative Dermatology

Year:

2004

Language:

english

File:

PDF, 750 KB

english, 2004

12

No evidence for ‘stress’ α-globin genes in chicken

Knöchel, Walter, Wittig, Burghardt, Wittig, Stephanie, John, Maliyakal E., Grundmann, Ulrich, Oberthür, Walter, Godovac, Jasminka, Braunitzer, Gerhard

Journal:

Year:

1982

File:

PDF, 386 KB

1982

13

Function of a tRNA gene promoter depends on nucleosome position

Wittig, Stephanie, Wittig, Burghardt

Journal:

Year:

1982

File:

PDF, 1.74 MB

1982

14

Increased non-major histocompatibility complex-restricted lytic activity in melanoma patients vaccinated with cytokine gene-transfected autologous tumor cells

Möller, Peter, Möller, Hjördis, Sun, Yuansheng, Dorbic, Tomislav, Henz, Beate M, Wittig, Burghardt, Schadendorf, Dirk

Journal:

Cancer Gene Therapy

Year:

2000

Language:

english

File:

PDF, 269 KB

english, 2000

15

One- and Two-Photon Excited Optical pH Probing for Cells Using Surface-Enhanced Raman and Hyper-Raman Nanosensors

Kneipp, Janina, Kneipp, Harald, Wittig, Burghardt, Kneipp, Katrin

Journal:

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

16

Minimizing side effects of ballistic gene transfer into the murine corneal epithelium

Er-Ping Zhang, Anja Müller, Felix Schulte, Sven A. König Merediz, Florian Sack, Claas Junghans, Burghardt Wittig, Friedrich Hoffmann

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

2002

Language:

english

File:

PDF, 121 KB

english, 2002

17

Influence of ballistic gene transfer on antigen-presenting cells in murine corneas

Anja Müller, Er-Ping Zhang, Matthias Schroff, Burghardt Wittig, Friedrich Hoffmann

Journal:

Graefe's Archive for Clinical and Experimental Ophthalmology

Year:

2002

Language:

english

File:

PDF, 576 KB

english, 2002

18

Identification of transcriptionally induced Z-DNA segments in the human c-myc gene

Stefan Wölfl, Burghardt Wittig, Alexander Rich

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1995

Language:

english

File:

PDF, 912 KB

english, 1995

19

Schistosoma mansoni miracidia transformed by particle bombardment infect Biomphalaria glabrata snails and develop into transgenic sporocysts

Oliver Heyers, Anna K. Walduck, Paul J. Brindley, Wilfrid Bleiß, Richard Lucius, Tomislav Dorbic, Burghardt Wittig, Bernd H. Kalinna

Journal:

Experimental Parasitology

Year:

2003

Language:

english

File:

PDF, 1.03 MB

english, 2003

20

Identification of processes that influence negative supercoiling in the human c-myc gene

Stefan Wölfl, Burghardt Wittig, Tomislav Dorbic, Alexander Rich

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1997

Language:

english

File:

PDF, 404 KB

english, 1997

21

Simultaneous identification of long similar substrings in large sets of sequences

Jürgen Kleffe, Friedrich Möller, Burghardt Wittig

Journal:

BMC Bioinformatics

Year:

2007

Language:

english

File:

PDF, 669 KB

english, 2007

22

Studies on Phenylalanine-Specific Transfer Ribonucleic Acid from Chick Embryos

Burghardt WITTIG, Stephanie REUTER, Hubert GOTTSCHLING

Journal:

Year:

1974

Language:

english

File:

PDF, 779 KB

english, 1974

23

Transcription termination and processing of transcripts from tRNA-related Xenopus satellite DNA sequences

Wolfgang MEYERHOF, Burghardt WITTIG, Beatrix TAPPESER, Walter KNÖCHEL

Journal:

Year:

1987

Language:

english

File:

PDF, 790 KB

english, 1987

24

COMPARISON OF NON-VIRAL TRANSFECTION METHODS IN MELANOMA CELL PRIMARY CULTURES

Bettina Micka, Beate Trojaneck, Sigrun Niemitz, Petja Lefterova, Susanne Kruopis, Dieter Huhn, Burghardt Wittig, Dirk Schadendorf, Ingo G.H Schmidt-Wolf

Journal:

Year:

2000

Language:

english

File:

PDF, 109 KB

english, 2000

25

Purification of the four lysine-specific transfer ribonucleic acids from chick embryos

Burghardt Wittig, Stephanie Reuter, Hubert Gottschling

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1973

Language:

english

File:

PDF, 504 KB

english, 1973

26

Purification of class A, B, and C DNA-dependent RNA polymerases from chicken embryos

Burghardt Wittig, Stephanie Wittig

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1978

Language:

english

File:

PDF, 1.23 MB

english, 1978

27

A functional approach to the mapping of structural polymorphisms in superhelical DNA

Carsten Carlberg, Burghardt Wittig

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 135 KB

english, 1988

28

The enrichment of chicken embryo tRNA genes in nucleosomal DNA by reversed phase chromatography

Burghardt Wittig, Stephanie Wittig

Journal:

Year:

1979

Language:

english

File:

PDF, 468 KB

english, 1979

29

A specific Go heterotrimer couples somatostatin receptors to voltage-gated calcium channels in RINm5F cells

Vadim E. Degtiar, Burghardt Wittig, Günter Schultz, Frank Kalkbrenner

Journal:

Year:

1996

Language:

english

File:

PDF, 443 KB

english, 1996

30

Effect of different nuclear localization sequences on the immune responses induced by a MIDGE vector encoding bovine herpesvirus-1 glycoprotein D

Chunfu Zheng, Christiane Juhls, Detlef Oswald, Florian Sack, Ines Westfehling, Burghardt Wittig, Lorne A. Babiuk, Sylvia van Drunen Littel-van den Hurk

Journal:

Year:

2006

Language:

english

File:

PDF, 306 KB

english, 2006

31

Anti-tumor effect of DNA-based vaccination and dSLIM immunomodulatory molecules in mice with Ph+ acute lymphoblastic leukaemia

Joachim Köchling, Javier Prada, Masoud Bahrami, Renata Stripecke, Karl Seeger, Günter Henze, Burghardt Wittig, Manuel Schmidt

Journal:

Year:

2008

Language:

english

File:

PDF, 440 KB

english, 2008

32

Immune response induced by a linear DNA vector: Influence of dose, formulation and route of injection

Anne Endmann, Michael Baden, Elena Weisermann, Kerstin Kapp, Matthias Schroff, Christiane Kleuss, Burghardt Wittig, Christiane Juhls

Journal:

Year:

2010

Language:

english

File:

PDF, 808 KB

english, 2010

33

The innate antiviral immune system of the cat: Molecular tools for the measurement of its state of activation

Céline Robert-Tissot, Vera L. Rüegger, Valentino Cattori, Marina L. Meli, Barbara Riond, Maria Alice Gomes-Keller, Andrea Vögtlin, Burghardt Wittig, Christiane Juhls, Regina Hofmann-Lehmann, Hans Lutz

Journal:

Veterinary Immunology and Immunopathology

Year:

2011

Language:

english

File:

PDF, 593 KB

english, 2011

34

Specificity of interaction between receptor and G protein: use of antisense techniques to relate G-protein subunits to function

Frank Kalkbrenner, Edgar Dippel, Burghardt Wittig, Günter Schultz

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1996

Language:

english

File:

PDF, 1.31 MB

english, 1996

35

Stabilization of R loop structures by photochemical crosslinking with 4,5′,8-trimethylpsoralen: Application to gene enrichment and molecular cloning

Burghardt Wittig, Stephanie Wittig

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 559 KB

english, 1979

36

Prevention and synergistic control of Ph+ ALL by a DNA vaccine and 6-mercaptopurine

Joachim Köchling, Yvonne Rott, Stefanie Arndt, Christina Marschke, Manuel Schmidt, Burghardt Wittig, Katrin Kalies, Jürgen Westermann, Günter Henze

Journal:

Year:

2012

Language:

english

File:

PDF, 365 KB

english, 2012

37

Retinoic acid receptor γ1 expression determines retinoid sensitivity in pancreatic carcinoma cells

Astrid Kaiser, Maja Wolf–Breitinger, Andreas Albers, Tomislav Dorbic, Burghardt Wittig, Ernst–Otto Riecken, Stefan Rosewicz

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 634 KB

english, 1998

38

Heat shock gene expression is regulated during teratocarcinoma cell differentiation and early embryonic development

Stephanie Wittig, Sigrid Hensse, Christiane Keitel, Christine Elsner, Burghardt Wittig

Journal:

Developmental Biology

Year:

1983

Language:

english

File:

PDF, 7.58 MB

english, 1983

39

Following the Dynamics of pH in Endosomes of Live Cells with SERS Nanosensors †

Kneipp, Janina, Kneipp, Harald, Wittig, Burghardt, Kneipp, Katrin

Journal:

The Journal of Physical Chemistry C

Year:

2010

Language:

english

File:

PDF, 2.71 MB

english, 2010

40

Preclinical study on combined chemo- and nonviral gene therapy for sensitization of melanoma using a human TNF-alpha expressing MIDGE DNA vector

Kobelt, Dennis, Aumann, Jutta, Schmidt, Manuel, Wittig, Burghardt, Fichtner, Iduna, Behrens, Diana, Lemm, Margit, Freundt, Greta, Schlag, Peter M., Walther, Wolfgang

Journal:

Molecular Oncology

Year:

2014

Language:

english

File:

PDF, 1.46 MB

english, 2014

41

A phase relationship associates tRNA structural gene sequences with nucleosome cores

Wittig, Burghardt, Wittig, Stephanie

Journal:

Year:

1979

Language:

english

File:

PDF, 4.38 MB

english, 1979

42

Z-DNA-Forming Sites within the Human β -Globin Gene Cluster

Verena Müller, Mieko Takeya, Susanne Brendel, Burghardt Wittig and Alexander Rich

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.23 MB

english, 1996

43

A Heterotrimeric G Protein Complex Couples the Muscarinic m1 Receptor to Phospholipase C-β

Edgar Dippel, Frank Kalkbrenner, Burghardt Wittig and Günter Schultz

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 331 KB

english, 1996

44

The Level of Z-DNA in Metabolically Active, Permeabilized Mammalian Cell Nuclei Is Regulated by Torsional Strain

Burghardt Wittig, Tomislav Dorbic and Alexander Rich

Journal:

The Journal of Cell Biology

Year:

1989

Language:

english

File:

PDF, 2.59 MB

english, 1989

45

Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial

Schmoll, Hans-Joachim, Wittig, Burghardt, Arnold, Dirk, Riera-Knorrenschild, Jorge, Nitsche, Dieter, Kroening, Hendrik, Mayer, Frank, Andel, Johannes, Ziebermayr, Reinhard, Scheithauer, Werner

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

2014

Language:

english

File:

PDF, 699 KB

english, 2014

46

Construction of a 42 base pair double stranded DNA microcircle

Wolters, Mark, Wittig, Burghardt

Journal:

Nucleic Acids Research

Year:

1989

Language:

english

File:

PDF, 2.40 MB

english, 1989

47

Interleukin-7 Gene Transfer in Patients with Metastatic Colon Carcinoma, Renal Cell Carcinoma, Melanoma, or with Lymphoma. Universitaetsklinikum Rudolf Virchow, Standort Charlottenburg, Germany

Schmidt-Wolf, Ingo G. H., Huhn, Dieter, Neubauer, Andreas, Wittig, Burghardt

Journal:

Human Gene Therapy

Year:

1994

Language:

english

File:

PDF, 578 KB

english, 1994

48

Gi2and Protein Kinase C are Required for Thyrotropin-Releasing Hormone-Induced Stimulation of Voltage-Dependent Ca2+Channels in Rat Pituitary GH3Cells

Maik Gollasch, Christiane Kleuss, Jurgen Hescheler, Burghardt Wittig and Gunter Schultz

Journal:

Proceedings of the National Academy of Sciences

Year:

1993

Language:

english

File:

PDF, 994 KB

english, 1993

49

Genuine Immunomodulation With dSLIM

Kapp, Kerstin, Kleuss, Christiane, Schroff, Matthias, Wittig, Burghardt

Journal:

Molecular Therapy — Nucleic Acids

Year:

2014

Language:

english

File:

PDF, 763 KB

english, 2014

50

426. dSLIM Immunomodulators Induce Anti- Tumor Responses Both In Vitro and In Vivo

Schmidt, Manuel, Cristobal, Javier, Sander, Astrid, Brzezicha, Bernadette, Konig Merediz, Sven A., Wittig, Burghardt

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 84 KB

english, 2006

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